A Comparison of Type IV Hypersensitivity Reaction to Synthetic Polyisoprene Gloves versus Control Gloves Using Modified Draize-95 Test in Normal Individual

Background: The emergence of epidemics in recent years, such as COVID-19 and monkeypox, has increased the need for protective gloves. Objectives: This study was performed to provide clinical evidence that no residual chemical additives are present powder-free, non-latex, with without pigment, sterile non-sterile nitrile, polyisoprene gloves at a level may induce type IV allergy unsensitized general user population. Methods Materials: We conducted modified Draize-95 test on GAMMEX® Non-Latex PI, powder-free synthetic surgical (S01) PI Green, powder free (S02). A quasi-experimental non-equivalent consisted 180 healthy adult volunteers Islamic University Gaza. Participants were divided into two groups: 150 white subjects 30 black subjects. Each group groups, each one contained approximately same numbers males females. used sets different materials 2x2 cm pieces glove's from inner outer surfaces mounted an adhesive patch. For control we Nitrile Skin Examination Powder-Free Disposable Gloves (C1) Aegis (C2). Results: None participants showed positive reactions equal or greater than 1.5 challenge rechallenge phase, both (S01), Only woman reaction surface S02 material induction phase. Three skin second material, Those three female phase However, none them any later. Conclusion: Draize negative results GAMMEX (white green) support claim sensitization potential these is low could cause hypersensitivity reactions.